Z-Endoxifen

CAS No.	112093-28-4	Cat. No.	BCP18471
Name	Z-Endoxifen
Synonyms	Endoxifen Z-isomer;Endoxifen;(Z)-4-Hydroxy-N-desmethyl Tamoxifen;
Formula	C25H27NO2	M. Wt	373.49

Description	Endoxifen is considered a prodrug, since it has a much higher potency for the estrogen receptor than its parent drug. Endoxifen inhibits the hERG channel protein trafficking to the plasma membrane in a concentration-dependent manner with Endoxifen being more potent than Tamoxifen.Endoxifen is also shown to be a more potent inhibitor of estrogen target genes when ERβ is expressed. Additionally, low concentrations of Endoxifen observed in Tamoxifen treated patients with deficient CYP2D6 activity (20 to 40 nM) markedly inhibit estrogen-induced cell proliferation rates in the presence of ERβ, whereas much higher Endoxifen concentrations are needed when ERβ is absent.
Pathways	Hormone Pathay
Targets	Estrogen Receptor

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