Thapsigargin
| CAS No. | 67526-95-8 | Cat. No. | BCP18539 |
| Name | Thapsigargin | ||
| Synonyms | |||
| Formula | C34H50O12 | M. Wt | 650.75 |
| Description | Thapsigargin is a non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). It is a potent, cell-permeable, IP3-independent intracellular calcium releaser, that works by blocking the transient increase in intracellular Ca2+ induced by angiostatin and endostatin, and inducing apoptosis by disrupting intracellular free Ca2+ levels. | ||
| Pathways | Ion Channel/Membrane Transporter | ||
| Targets | ATPase | ||
Structure
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