Netarsudil mesylate

CAS No.	1422144-42-0	Cat. No.	BCP24703
Name	Netarsudil mesylate
Synonyms	AR-13324 mesylate;AR13324 mesylate;AR 13324 mesylate;
Formula	C30H35N3O9S2	M. Wt	645.74

Description	Netarsudil, also known as AR-11324, is a Rho-associated protein kinase inhibitor. Netarsudil is potential useful for treating glaucoma and/or reducing intraocular pressure. Netarsudil Increases Outflow Facility in Human Eyes Through Multiple Mechanisms. Netarsudil inhibited kinases ROCK1 and ROCK2 with a Ki of 1 nM each, disrupted actin stress fibers and focal adhesions in TM cells with IC50s of 79 and 16 nM, respectively, and blocked the profibrotic effects of TGF-β2 in HTM cells. Netarsudil produced large reductions in IOP in rabbits and monkeys that were sustained for at least 24 h after once daily dosing, with transient, mild hyperemia observed as the only adverse effect.
Pathways	Cell Cycle/DNA Damage TGF beta/Smad Wnt/Stem Cell
Targets	ROCK

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