AM2394
| CAS No. | 1442684-77-6 | Cat. No. | BCP18588 |
| Name | AM2394 | ||
| Synonyms | AM-2394;AM 2394; | ||
| Formula | C22H25N5O4 | M. Wt | 423.47 |
| Description | AM-2394 is a potent and selective Glucokinase agonist (GKA), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394 activates GK with an EC50 of 60 nM, increases the affinity of GK for glucose by approximately 10-fold, exhibits moderate clearance and good oral bioavailability in multiple animal models, and lowers glucose excursion following an oral glucose tolerance test in an ob/ob mouse model of diabetes. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Glucokinase | ||
Structure
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