ONO-4059
| CAS No. | 1351636-18-4 | Cat. No. | BCP18777 |
| Name | ONO-4059 | ||
| Synonyms | ONO4059;ONO 4059;GS4059;GS-4059;GS 4059; | ||
| Formula | C25H22N6O3 | M. Wt | 454.48 |
| Description | In vitro: The compound covalently bonds to BTK, inhibiting BCR signaling and B-cell proliferation and activation. NO/GS-4059 induced durable responses in relapsed/refractory B-cell malignancies without significant toxicities. In vivo: ONO-4059 demonstrated therapeutic efficacy in a mouse arthritis model, and based on its anti-proliferative activity in B-cells. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | BTK | ||
Structure
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