索马鲁肽
CAS号 | 910463-68-2 | 货号 | BCP24773 |
中文名 | 索马鲁肽 | ||
英文名 | Semaglutide | ||
中文别名 | 西玛鲁肽;索玛鲁肽; | ||
英文别名 | OG217SC; NNC 0113-0217;Ozempic;NN 9535;NN9535;NN-9535; NNC 0113-0217; NNC-0113-0217; NNC0113-0217; | ||
分子式 | C187H291N45O59 | 分子量 | 4113.64 |
生物活性 | Semaglutide is a glucagon like peptide 1 (GLP-1) receptor peptidomimetic agonist. Structurally it is a modified analogue of glucagon-like peptide 1-(7-37) with amino acids at positions 8 and 34 replaced by α-aminobutyric acid and arginine respectively, and Lys26 is acylated with stearic diacid. Semaglutide has slightly lower GLP-1 receptor affinity than liraglutide, but this is compensated by an increased serum albumin affinity, which ensures improved resistance to metabolic degradation. | ||
信号通路 | GPCR/G Protein | ||
靶 点 | Glucagon Receptor |
结构式
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