CCT245737
| CAS No. | 1489389-18-5 | Cat. No. | BCP18991 |
| Name | CCT245737 | ||
| Synonyms | CCT-245737;CCT 245737; | ||
| Formula | C16H16F3N7O | M. Wt | 379.34 |
| Description | In vitro: CCT245737 shows <50% inhibition at 10 μM for 85/121 kinases, representing a selectivity for CHK1 inhibition of >5000-fold over these enzymes. [1] CCT245737 enhanced gemcitabine antitumor activity to a greater degree than for higher doses of either agent alone, without increasing toxicity. In vivo: CCT2457374 shows an increase in plasma and tumoconcentrations between 3?100 mg/kg po. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Checkpoint | ||
Structure
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