Angiotensin 1-7

CAS No.	51833-78-4	Cat. No.	BCP19018
Name	Angiotensin 1-7
Synonyms	TXA127; TXA 127; TXA127; Angiotensin i (1-7); therapeutic angiotensin(17);
Formula	C41H62N12O11	M. Wt	899.02

Description	Angiotensin i (1-7) is a synthetic heptapeptide identical to endogenous angiotensin-(1-7) with vasodilator and antiproliferative activities. Therapeutic angiotensin 1-7 may inhibit cyclooxygenase 2 (COX-2) and the production of proinflammatory prostaglandins and may activate the angiotensin-(1-7) receptor Mas, resulting in diminished tumor cell proliferation. Activation of the angiotensin-(1-7) receptor Mas, a G-protein coupled, seven transmembrane protein, may down-regulate the phophorylation and activation of Erk1 and Erk2 in the Erk1/Erk2 Mapk signaling pathway.
Pathways	Protease/Metabolic Enzyme Hormone Pathay GPCR/G Protein
Targets	Angiotensin Receptor RAAS/ACE

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