Dulcitol diepoxide

  • Chemical Properties
CAS No. 23261-20-3 Cat. No. BCP19033
Name Dulcitol diepoxide
Synonyms Dianhydrogalactitol;VAL-083;VAL083;VAL 083;
Formula C6H10O4 M. Wt 146.14
  • Biological Activity
Description VAL-083 inhibited U251 and SF188 cell growth in monolayer and as neurospheres better than TMZ and caused apoptosis after 72 hr. In the colony formation assay, VAL-083 (5 uM) suppressed SF188 growth by about 95%. T98G cells are classically TMZ-resistant and express MGMT, but VAL-083 inhibited their growth in monolayer after 72 hr in a dose-dependent manner (IC50, 5 uM). VAL-083 also inhibited the growth of CSCs (BT74, GBM4, and GBM8) by 80-100% in neurosphere self-renewal assays. Conversely, there was minimal effect on normal human neural stem cells.
Pathways Cell Cycle/DNA Damage 
Targets DNA Alkylator/Crosslinker 

Structure

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