Dulcitol diepoxide
CAS No. | 23261-20-3 | Cat. No. | BCP19033 |
Name | Dulcitol diepoxide | ||
Synonyms | Dianhydrogalactitol;VAL-083;VAL083;VAL 083; | ||
Formula | C6H10O4 | M. Wt | 146.14 |
Description | VAL-083 inhibited U251 and SF188 cell growth in monolayer and as neurospheres better than TMZ and caused apoptosis after 72 hr. In the colony formation assay, VAL-083 (5 uM) suppressed SF188 growth by about 95%. T98G cells are classically TMZ-resistant and express MGMT, but VAL-083 inhibited their growth in monolayer after 72 hr in a dose-dependent manner (IC50, 5 uM). VAL-083 also inhibited the growth of CSCs (BT74, GBM4, and GBM8) by 80-100% in neurosphere self-renewal assays. Conversely, there was minimal effect on normal human neural stem cells. | ||
Pathways | Cell Cycle/DNA Damage | ||
Targets | DNA Alkylator/Crosslinker |
Structure
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