醋酸萘法瑞林
| CAS号 | 86220-42-0 | 货号 | BCP19032 |
| 中文名 | 醋酸萘法瑞林 | ||
| 英文名 | Nafarelin Acetate | ||
| 中文别名 | |||
| 英文别名 | RS 94991 298;RS-94991-298;RS94991298; | ||
| 分子式 | C68H89N17O16 | 分子量 | 1400.54 |
| 生物活性 | Nafarelin Acetate is the acetate salt form of nafarelin, a modified synthetic porcine luteinizing hormone (LH)-releasing hormone peptide analog, with gonadotropin-releasing hormone (GnRH) agonist activity.Nafarelin is a gonadotropin-releasing hormone agonist (GnRH agonist) which acts as an analog of GnRH. Nafarelin increases the release of FSH and LH by the anterior pituitary, which in turn leads to an increase of estrogen/progesterone. When administered, Nafarelin has the purpose of causing increase estrogen that will negatively feed back upon hypothalamus to decrease GnRH ( negative feedback loop ) Through negative feedback, Nafarelin causes a decrease in pituitary secretion of gonadotropins luteinizing hormone (LH) and follicle stimulating hormone (FSH). Nafarelin may be used in the treatment of estrogen-dependent conditions (such as endometriosis or uterine fibroids), to treat central precocious puberty, and to control ovarian stimulation in IVF. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | GnRH Receptor | ||
结构式
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