(+/-)-Roscovitine
| CAS No. | 186692-44-4 | Cat. No. | BCP19053 |
| Name | (+/-)-Roscovitine | ||
| Synonyms | R-roscovitine;CYC202; CYC202; CYC 202;Seliciclib; | ||
| Formula | C19H26N6O | M. Wt | 354.46 |
| Description | Seliciclib, also known as roscovitine and CYC202, is a n orally bioavailable, small-molecule cyclin-dependent kinase (CDK) inhibitor with potential proapoptotic and antineoplastic activities. Seliciclib primarily inhibits CDK2/E, CDK2/A, CDK7 and CDK9 by competing for their ATP binding sites, leading to a disruption of cell cycle progression. In addition, this agent appears to interfere with CDK-mediated phosphorylation of the carboxy-terminal domain of RNA polymerase II, inhibiting RNA polymerase II-dependent transcription, which may result in the down-regulation of antiapoptotic proteins such as induced myeloid leukemia cell differentiation protein Mcl-1. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | CDK | ||
Structure
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