SA-4503 dihydrochloride
| CAS No. | 165377-44-6 | Cat. No. | BCP19110 |
| Name | SA-4503 dihydrochloride | ||
| Synonyms | AGY94806 dihydrochloride; SA-4503 HCl;SA 4503 dihydrochloride;SA4503 dihydrochloride; AGY94806; AGY-94806; AGY 94806; Cutamesine HCl; | ||
| Formula | C23H32N2O2.2ClH | M. Wt | 441.44 |
| Description | SA4503 dihydrochloride is a potent σ1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.Cutamesine, also known as SA-4503 and AGY94806, is a sigma-1 receptor agonist under development for recovery enhancement after acute ischemic stroke. Cutamesine protects against retinal cell death in vitro and in vivo by the agonistic effect of sigma-1 receptor. Therefore, sigma-1 receptor may have a potential as a therapeutic target in retinal diseases mediated by photoreceptor degeneration. | ||
| Pathways | GPCR/G Protein | ||
| Targets | Sigma Receptor | ||
Structure
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