AZ-876
| CAS No. | 898800-26-5 | Cat. No. | BCP19166 |
| Name | AZ-876 | ||
| Synonyms | AZ 876;AZ876; | ||
| Formula | C24H29N3O3S | M. Wt | 439.57 |
| Description | (1) AZ876 suppressed up-regulation of hypertrophy- and fibrosis-related genes, and further inhibited prohypertrophic and profibrotic transforming growth factor β (TGFβ)-Smad2/3 signalling. (2) AZ876 prevented TGFβ- and angiotensin II-induced fibroblast collagen synthesis, and inhibited up-regulation of the myofibroblastic marker, α-smooth muscle actin. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | LXR | ||
Structure
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