Diethylnorspermine HCl

CAS No.	156886-85-0	Cat. No.	BCP19157
Name	Diethylnorspermine HCl
Synonyms	Diethylnorspermine; BE-333; BENSPM; CI-1006; DE-333; DENSPM; BE333; CI1006; DE333;
Formula	C13H32N4.4HCl	M. Wt	390.26

Description	Diethylnorspermine, also known as DENSPM, is a potent inducer of spermidine/spermine N1-acetyltransferase, is able to increase enzyme activity 200-1000 fold. The cell death induced by DENSPM treatment was apoptotic, as evidenced by cleavage of procaspase 3 and induction of caspase-3 activity. The DENSPM-induced polyamine depletion was also caused by the inhibition of ornithine decarboxylase. LA-N-1 cells contained a higher level of the prosurvival protein survivin, which was further increased after DENSPM treatment.
Pathways	Others Pathway
Targets	Others

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