Dofequidar
| CAS号 | 129716-58-1 | 货号 | BCP24839 |
| 中文名 | Dofequidar | ||
| 英文名 | Dofequidar | ||
| 中文别名 | |||
| 英文别名 | MS-209; MS 209; MS209; | ||
| 分子式 | C30H31N3O3 | 分子量 | 481.593 |
| 生物活性 | Dofequidar, also known as MS-209, is a quinolone-derived sphingomyelin synthase inhibitor that blocks P-glycoprotein and multidrug resistance-associated protein-1, is under development by Schering for the potential treatment of multidrug resistant tumors. Dofequidar was found to sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export. | ||
| 信号通路 | Ion Channel/Membrane Transporter | ||
| 靶 点 | P glycoprotein | ||
结构式
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