Pimodivir

CAS No.	1629869-44-8	Cat. No.	BCP19446
Name	Pimodivir
Synonyms	VX-787; VX 787; VX787; JNJ-63623872; JNJ63623872; JNJ 63623872; JNJ-872; JNJ 872; JNJ872; VRT-0928787; VRT 0928787; VRT0928787;
Formula	C20H19F2N5O2	M. Wt	399.4

Description	Pimodivir, also known as VX-787, JNJ-872, is a novel inhibitor of influenza virus replication that blocks the PB2 cap-snatching activity of the influenza viral polymerase complex. VX-787 binds the cap-binding domain of the PB2 subunit with a KD (dissociation constant) of 24 nM as determined by isothermal titration calorimetry (ITC). The cell-based EC50 (the concentration of compound that ensures 50% cell viability of an uninfected control) for VX-787 is 1.6 nM in a cytopathic effect (CPE) assay, with a similar EC50 in a viral RNA replication assay. VX-787 is active against a diverse panel of influenza A virus strains, including H1N1pdm09 and H5N1 strains, as well as strains with reduced susceptibility to neuraminidase inhibitors (NAIs).
Pathways	Microbiology/Virology
Targets	Influenza Virus

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