AZD0914

CAS No.	1620458-09-4	Cat. No.	BCP19546
Name	AZD0914
Synonyms	ETX0914; ETX-0914; ETX 0914;Zoliflodacin;AZD-0914;AZD 0914;
Formula	C22H22FN5O7	M. Wt	487.44

Description	AZD0914, also known as Zoliflodacin and ETX0914, is a new spiropyrimidinetrione bacterial DNA gyrase/topoisomerase inhibitor with potent in vitro antibacterial activity against key Gram-positive (Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Streptococcus pyogenes, and Streptococcus agalactiae), fastidious Gram-negative (Haemophilus influenzae and Neisseria gonorrhoeae), atypical (Legionella pneumophila), and anaerobic (Clostridium difficile) bacterial species, including isolates with known resistance to fluoroquinolones. AZD0914 works via inhibition of DNA biosynthesis and accumulation of double-strand cleavages.
Pathways	Microbiology/Virology Cell Cycle/DNA Damage
Targets	DNA/RNA Synthesis Antibiotic

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