LY2922470
| CAS No. | 1423018-12-5 | Cat. No. | BCP24962 |
| Name | LY2922470 | ||
| Synonyms | LY-2922470; LY 2922470; | ||
| Formula | C28H29NO4S | M. Wt | 475.6 |
| Description | LY2922470 is a Potent and Selective GPR40 Agonist for the Treatment of Type 2 Diabetes Mellitus. LY2922470 demonstrated potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion during preclinical testing. The G protein-coupled receptor 40 (GPR40) also known as Free Fatty Acid Receptor 1 (FFAR1) is highly expressed in pancreatic, islet beta-cells and responds to endogenous fatty acids resulting in amplification of insulin secretion only in the presence of elevated glucose levels. | ||
| Pathways | GPCR/G Protein | ||
Structure
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