3-MATIDA
| CAS No. | 518357-51-2 | Cat. No. | BCP24974 |
| Name | 3-MATIDA | ||
| Synonyms | |||
| Formula | C8H9NO4S | M. Wt | 215.23 |
| Description | 3-MATIDA is a potent metabotropic glutamate mGlu1 receptor antagonist (IC50 = 6.3 μM at rat mGlu1a). Displays ≥ 40-fold selectivity over other receptors: mGlu5, mGlu2, mGlu4a (IC50 > 300 μM), NMDA and AMPA (IC50 = 250 μM). Neuroprotective in cultured murine cortical cells and rat hippocampal slice cultures in vitro. Reduces the volume of ischemia-induced brain infarcts in rats following systemic administration in vivo. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | mGluR | ||
Structure
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