Nelotanserin
| CAS No. | 839713-36-9 | Cat. No. | BCP24992 |
| Name | Nelotanserin | ||
| Synonyms | APD125; APD-125; APD 125; | ||
| Formula | C18H15BrF2N4O2 | M. Wt | 437.24 |
| Description | Nelotanserin, also known as APD125, is a potent and selective human 5-hydroxytryptamine2A inverse agonist for the treatment of insomnia. Nelotanserin has low nanomolar potency on the 5-HT(2A) receptor with at least 30- and 5000-fold selectivity compared with 5-HT(2C) and 5-HT(2B) receptors, respectively. Nelotanserin produced statistically significant improvements in objective parameters of sleep maintenance and sleep consolidation and was well tolerated in adults with primary chronic insomnia. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | 5 HT Receptor/Serotonin Receptor | ||
Structure
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