Silatecan
| CAS No. | 220913-32-6 | Cat. No. | BCP19768 |
| Name | Silatecan | ||
| Synonyms | AR67; AR 67; AR67; DB67; DB 67; DB67; | ||
| Formula | C26H30N2O5Si | M. Wt | 478.61 |
| Description | Silatecan (AR-67) is a synthetic, highly lipophilic derivative of camptothecin, with potential antineoplastic and radiosensitizing activities. Silatecan DB-67 binds to and stabilizes the topoisomerase I-DNA covalent complex, inhibiting the religation of topoisomerase I-mediated single-stranded DNA breaks and producing lethal double-stranded DNA breaks when encountered by the DNA replication machinery; inhibition of DNA replication and apoptosis follow. Camptothecin readily undergoes hydrolysis at physiological pH, changing its conformation from the active lactone structure to an inactive carboxylate form. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | Topoisomerase | ||
Structure
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