Debio 0617B
| CAS No. | 1332329-27-7 | Cat. No. | BCP25046 |
| Name | Debio 0617B | ||
| Synonyms | Debio 0617B;Debio0617B；Jak/Src Inhibitor 1; | ||
| Formula | C28H23ClF3N7O2 | M. Wt | 581.98 |
| Description | A first-in-class, multi-kinase inhibitor that targets pSTAT3 and/or pSTAT5 in cancer cells through combined inhibition of JAK, SRC, ABL, and class III/V RTKs (Kd<100 nM); showes dose-dependent inhibition of pSTAT3 in STAT3-activated carcinoma cell lines (IC50=175 nM); also showes potent antiproliferative activity in a panel of cancer cell lines and in patient-derived tumor xenografts. | ||
| Pathways | Jak/Stat Pathway Wnt/Stem Cell | ||
| Targets | Stat | ||
Structure
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