AMG-3969
| CAS No. | 1361224-53-4 | Cat. No. | BCP19926 |
| Name | AMG-3969 | ||
| Synonyms | AMG3969;AMG 3969; | ||
| Formula | C21H20F6N4O3S | M. Wt | 522.46 |
| Description | AMG-3969 is a GK-GKRP disruptor. AMG-3969 normalized blood glucose levels in several rodent models of diabetes. AMG-3969 potently reversed the inhibitory effect of GKRP on GK activity and promoted GK translocation both in vitro (isolated hepatocytes) and in vivo (liver). AMG-3969 blood glucose lowering was restricted to diabetic and not normoglycaemic animals. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Glucokinase | ||
Structure
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