ETP-46321
| CAS No. | 1252594-99-2 | Cat. No. | BCP19935 |
| Name | ETP-46321 | ||
| Synonyms | ETP46321;ETP 46321; | ||
| Formula | C20H27N9O3S | M. Wt | 473.55 |
| Description | ETP-46321, has been pro?led and shown to be a potent PI3K a and d inhibitor, highly selective versus mTOR and 288 representative kinases. The compound demonstrated a good pharmacokinetic profile in mice and was selected for preliminary in vivo evaluation in a lung tumor mouse model driven by a K-Ras G12V oncogenic mutation, showing significant tumor growth inhibition (ca. 51%), and reduction of the tumor metabolic activity as measured by PET techniques. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PI3K | ||
Structure
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