UK-371804
| CAS No. | 256477-09-5 | Cat. No. | BCP19928 |
| Name | UK-371804 | ||
| Synonyms | UK 371804;UK371804;Urokinase inhibitor 1; UK-371,804; UK 371,804; UK371,804; | ||
| Formula | C14H16ClN5O4S | M. Wt | 385.82 |
| Description | UK-371804 is a potent and selective uPA inhibitor with excellent enzyme potency (Ki 10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). In vitro, UK-371804 is able to inhibit exogenous uPA in human chronic wound fluid (IC50=0.89 microM). In vivo, in a porcine acute excisional wound model, following topical delivery, UK-371804 is able to penetrate into pig wounds and inhibit exogenous uPA activity with no adverse effect on wound healing parameters. UK-371804 was selected as a candidate for further preclinical evaluation for the treatment of chronic dermal ulcers. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Serine Protease | ||
Structure
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