Edicotinib
  • 化学数据
CAS号 1142363-52-7 货号 BCP25086
中文名 Edicotinib
英文名 Edicotinib
中文别名
英文别名 JNJ40346527; JNJ 40346527; JNJ-40346527;
分子式 C27H35N5O2 分子量 461.61
  • 用途
生物活性 Edicotinib, also known as JNJ-40346527, is a small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; FMS) with potential antineoplastic activity. FMS tyrosine kinase inhibitor JNJ-40346527 blocks the receptor-ligand interaction between FMS and its ligand CSF1, thereby preventing autophosphorylation of FMS. As a result, unphosphorylated FMS cannot activate FMS-mediated signaling pathways, thus potentially inhibiting cell proliferation in FMS-overexpressed tumor cells.
信号通路 Angiogenesis/Protein Tyrosine Kinase 
靶 点 cFMS 

结构式

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