Plecanatide

  • Chemical Properties
CAS No. 467426-54-6 Cat. No. BCP25087
Name Plecanatide
Synonyms SP-304; SP 304; SP304; Trulance;
Formula C65H104N18O26S4 M. Wt 1681.89
  • Biological Activity
Description Plecanatide is a structural analog of human uroguanylin, and similarly to uroguanylin, plecanatide functions as a guanylate cyclase-C (GC-C) agonist. Both plecanatide and its active metabolite bind to GC-C and act locally on the luminal surface of the intestinal epithelium. Activation of GC-C results in an increase in both intracellular and extracellular concentrations of cyclic guanosine monophosphate (cGMP).
Pathways GPCR/G Protein 
Targets Guanylate Cyclase 

Structure

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