Senexin A
| CAS No. | 1366002-50-7 | Cat. No. | BCP25089 |
| Name | Senexin A | ||
| Synonyms | |||
| Formula | C17H14N4 | M. Wt | 274.33 |
| Description | Senexin A is a potent and selective CDK8 inhibitor (IC50 = 280 nM). Senexin A binds to cdk19 in an ATP-competitive manner. Senexin A inhibits p21-induced transcription. Senexin A may exert the effects against the activation of tumor-promoting and pro-inflammatory secreted factors in the tumor microenvironment by preventing transcriptional activation of NFκB-induced genes. | ||
| Pathways | Cell Cycle/DNA Damage | ||
| Targets | CDK | ||
Structure
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