Paritaprevir dihydrate

CAS No.	1456607-71-8	Cat. No.	BCP20006
Name	Paritaprevir dihydrate
Synonyms	ATB450 dihydrate; ABT-450 dihydrate; ABT 450 dihydrate;
Formula	C40H43N7O7S.2(H2O)	M. Wt	801.91

Description	Paritaprevir, also known as ABT-450 or Veruprevir, is an acylsulfonamide inhibitor of the NS3-4A serine protease manufactured by Abbott Laboratories that shows promising results as a treatment of hepatitis C. When given in combination with ritonavir and ribavirin for 12 weeks, the rate of sustained virologic response at 24 weeks after treatment has been estimated to be 95% for those with hepatitis C virus genotype 1. Resistance to treatment with paritaprevir is uncommon, because it targets the binding site, but has been seen to arise due to mutations at positions 155 and 168 in NS3.
Pathways	Microbiology/Virology
Targets	HCV

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