PAT-505
| CAS No. | 1782070-22-7 | Cat. No. | BCP25107 |
| Name | PAT-505 | ||
| Synonyms | PAT 505; PAT 505; | ||
| Formula | C23H18ClF2N3O2S | M. Wt | 473.92 |
| Description | PAT-505 is a potent, selective, non-competitive type III autotaxin inhibitor. PAT-505 displays significant inhibition of ATX activity in plasma and liver tissue after oral administration. PAT-505 treatment results in a small, but significant, improvement in fibrosis with only minor improvements in hepatocellular ballooning and hepatic inflammation. PAT-505 may represent a novel therapeutic approach for the treatment of multiple fibrotic liver diseases, including NASH. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | Phosphodiesterase/PDE | ||
Structure
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