TAS-103

  • Chemical Properties
CAS No. 174634-08-3 Cat. No. BCP20029
Name TAS-103
Synonyms TAS 103;TAS103; BMS247615; BMS 247615; BMS-247615;
Formula C20H19N3O2 M. Wt 333.38
  • Biological Activity
Description TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be a potent topoisomerase II poison. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05). The combination with CDDP augmented the antitumor activity of TAS-103 (p<0.05), indicating that CDDP is one of the most potent candidates to be used in combination with TAS-103 . TAS-103 may be useful in the chemotherapy of colorectal cancer.
Related Products 174634-09-4(TAS-103 dihydrochloride)
Pathways Cell Cycle/DNA Damage 
Targets Topoisomerase 

Structure

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