Emedastine

CAS No.	87233-61-2	Cat. No.	BCP20085
Name	Emedastine
Synonyms	Emadine; Emedastina;KB 2413;KB-2413;KB2413;KG 2413;KG2413;KG-2413;
Formula	C17H26N4O	M. Wt	302.41

Description	Emedastine is a second generation, selective histamine H1 receptor antagonist with anti-allergic activity. Emedastine reversibly and competitively blocks histamine by binding to H1 receptors, thus blocking its downstream activity. As a result this agent interferes with mediator release from mast cells either by inhibiting calcium ion influx across mast cell/basophil plasma membrane or by inhibiting intracellular calcium ion release within the cells. In addition, emedastine may also inhibit the late-phase allergic reaction mediated through leukotrienes or prostaglandins, or by producing an anti-platelet activating factor effect. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeability in the conjunctiva. Emedastine does not affect adrenergic, dopamine, or serotonin receptors.
Pathways	Neuro Signaling Pathway GPCR/G Protein
Targets	Histamine Receptor

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