ROC-325

  • Chemical Properties
CAS No. 1859141-26-6 Cat. No. BCP20110
Name ROC-325
Synonyms ROC 325;ROC325;
Formula C28H27ClN4OS M. Wt 503.06
  • Biological Activity
Description ROC-325 is an autophagy inhibitor. ROC-325 exhibited superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in 12 different cancer cell lines with diverse genetic backgrounds. ROC-325 antagonized RCC growth and survival in an ATG5/7-dependent manner, induced apoptosis, and exhibited favorable selectivity.
Pathways Others Pathway 
Targets Autophagy 

Structure

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