STA-21
| CAS No. | 111540-00-2 | Cat. No. | BCP20158 |
| Name | STA-21 | ||
| Synonyms | STA 21;STA21;Ochromycinone;NSC 628869;NSC-628869;NSC628869; | ||
| Formula | C19H14O4 | M. Wt | 306.31 |
| Description | In cells, STA-21 inhibits Stat3 DNA binding activity, Stat3 dimerization, and Stat3-dependent luciferase activity. STA-21 remarkably inhibits the growth and the survival of the breast carcinoma cells MDA-MB-231, MDA-MB-435s, and MDA-MB-468 that express persistently activated Stat3. In RH30 and RD2 cells, STA-21 also inhibits cell viability and growth and induced apoptosis through caspases 3, 8 and 9 pathways. | ||
| Pathways | Jak/Stat Pathway Wnt/Stem Cell | ||
| Targets | Stat | ||
Structure
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