KDOAM-25
| CAS No. | KDOAM-25 | Cat. No. | BCP25150 |
| Name | KDOAM-25 | ||
| Synonyms | KDOAM 25; KDOAM25; GTPL8576; GTPL-8576; GTPL 8576; LQT; | ||
| Formula | C15H25N5O2 | M. Wt | 307.40 |
| Description | KDOAM-25, also known as GTPL8576, is a selective inihbitor of the KDM5 family histone demethylases JARID1A, JARID1B, JARID1C and JARID1D with IC50 values < 60 nM. KDOAM-25 Stops Cellular Demethylation of H3K4me3 at Transcription Start Sites and Proliferation of MM1S Myeloma Cells. KDOAM-25 shows biochemical half maximal inhibitory concentration values of <100 nM for KDM5A-D in vitro, high selectivity toward other 2-OG oxygenases sub-families, and no off-target activity on a panel of 55 receptors and enzymes. In human cell assay systems, KDOAM-25 has a half maximal effective concentration of ∼50 μM and good selectivity toward other demethylases. | ||
| Pathways | Epigenetics | ||
| Targets | Histone Demethylase | ||
Structure
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