比生群
| CAS号 | 78186-34-2 | 货号 | BCP20206 |
| 中文名 | 比生群 | ||
| 英文名 | Bisantrene | ||
| 中文别名 | |||
| 英文别名 | |||
| 分子式 | C22H22N8 | 分子量 | 398.46 |
| 生物活性 | Bisantrene shows an outstanding ability to form a complex with DNA. Bisantrene exhibits the most effective binding (even neglecting electrostatic contacts), followed by the 9-substituted compounds and finally by 1-IHA. Bisantrene congeners retained a remarkable capacity for binding to the single-stranded structure. In comparison with the Ki values found for double-stranded DNA, 9-IHA shows a 2-fold increase, 1-IHA maintains the same values, and aza-9-IHA exhibits a modest reduction. On the other hand, Bisantrene, although undergoing a 6-fold reduction in Ki, still exhibits an affinity constant of the order of 106 M-1. Bisantrene promots DNase I cleavage at oligopurine-oligopyrimidine tracts; conversely, it slightly reduces the cleavage activity at alternating purine-pyrimidine sequences. Bisantrene is an active new drug in the treatment of metastatic breast cancer. Bisantrene is an inhibitor of [3H]uridine incorporation into RNA and [3H]thymidine incorporation into DNA. | ||
| 上下游产品 | 71439-68-4（比生群二盐酸盐） | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Topoisomerase | ||
结构式
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