Vps34-PIK-III
| CAS No. | 1383716-40-2 | Cat. No. | BCP25171 |
| Name | Vps34-PIK-III | ||
| Synonyms | PIK-III; VPS34-IN2; VPS34-IN 2; VPS34-IN-2; | ||
| Formula | C17H17N | M. Wt | 319.36 |
| Description | Vps34-PIK-III is a potent and selective inhibitor of VPS34 with an IC50 of 18 nM.PIK-III, also known as VPS34-IN2, is a VPS34 inhibitor which blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo. PIK-III binds a unique hydrophobic pocket not present in related kinases such as PI(3)Kα. PIK-III acutely inhibits autophagy and de novo lipidation of LC3, and leads to the stabilization of autophagy substrates. . | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | PI3K | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.