CID16020046
| CAS No. | 834903-43-4 | Cat. No. | BCP20242 |
| Name | CID16020046 | ||
| Synonyms | CID-16020046;CID 16020046; | ||
| Formula | C25H19N3O4 | M. Wt | 425.44 |
| Description | IC50 value: 0.15 uM [1] Target: GPR55 antagonist In yeast cells expressing human GPR55, CID16020046 antagonized agonist-induced receptor activation. In human embryonic kidney(HEK293) cells stably expressing human GPR55, the compound behaved as an antagonist on LPI-mediated Ca2+ release and extracellular signal-regulated kinases activation, but not in HEK293 cells expressing cannabinoid receptor 1 or 2.CID16020046 concentration dependently inhibited LPI-induced activation of nuclear factor of activated T-cells (NFAT), nuclear factor k of activated B cells (NF-kB) and serum response element, translocation of NFAT and NF-kB, and GPR55 internalization. It reduced LPI-induced wound healing in primary human lung microvascular endothelial cells and reversed LPI-inhibited platelet aggregation. | ||
| Pathways | Hormone Pathay GPCR/G Protein | ||
| Targets | GPR | ||
Structure
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