R-268712

  • Chemical Properties
CAS No. 879487-87-3 Cat. No. BCP25191
Name R-268712
Synonyms R 268712; R268712;
Formula C20H18FN5O M. Wt 363.39
  • Biological Activity
Description R-268712 is an orally active and selective ALK-5 inhibitor, with an IC50 of 2.5 nM. R-268712 inhibits the phosphorylation of Smad3 in a dose-dependent manner with an IC50 of 10.4 nM. R-268712 suppresses glomerulonephritis as well as glomerulosclerosis by inhibiting TGF-β signaling, which can be used in studies of renal fibrosis and cancer.
Pathways Angiogenesis/Protein Tyrosine Kinase 
Targets ALK 

Structure

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