Clozapine
| CAS No. | 5786-21-0 | Cat. No. | BCP25196 |
| Name | Clozapine | ||
| Synonyms | HF 1854;HF-1854;HF1854; | ||
| Formula | C18H19ClN4 | M. Wt | 326.82 |
| Description | Clozapine is an antipsychotic used to treat schizophrenia. Clozapine is a potent antagonist of dopamine and a number of other receptors, with a Ki of 9.5 nM for M1 receptor.Clozapine is an atypical antipsychotic drug because it binds to serotonin as well as dopamine receptors. Clozapine is a partial agonist at the 5-HT1A subunit of the serotonin receptor, putatively improving depression, anxiety, and the negative cognitive symptoms associated with schizophrenia. A direct interaction of clozapine with the GABAB receptor has also been shown. GABAB receptor-deficient mice exhibit increased extracellular dopamine levels and altered locomotor behaviour equivalent to that in schizophrenia animal models. | ||
| Pathways | Neuro Signaling Pathway GPCR/G Protein | ||
| Targets | Dopamine Receptor | ||
Structure
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