CC220
| CAS No. | 1323403-33-3 | Cat. No. | BCP20299 |
| Name | CC220 | ||
| Synonyms | CC 220;CC-220;Iberdomide; | ||
| Formula | C25H27N3O5 | M. Wt | 449.5 |
| Description | Iberdomide, also known as CC-220, is a potent, next-generation modulator of cereblon E3 ubiquitin ligase with IC50 of 60 nM; exhibits significantly higher affinity than lenalidomide and pomalidomide (IC50=1.5 and 1.2 uM, respectively); reduces and degrades Aiolos and Ikaros protein levels (EC50=1 nM and 0.5 nM, respectively) and BAFF- and CD40L-induced proliferation, plasmablast differentiation, and IgG secretion in cellular degradation assay. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | E1 E2 E3 Enzyme | ||
Structure
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