BMS986205
| CAS No. | 1923833-60-6 | Cat. No. | BCP20339 |
| Name | BMS986205 | ||
| Synonyms | BMS986205;BMS 986205; ONO-7701; ONO 7701; ONO7701; F-001287; F001287; F001287; Linrodostat; | ||
| Formula | C24H24ClFN2O | M. Wt | 410.91 |
| Description | BMS-986205 is a potent and selective, orally active IDO1 inhibitor with potential immunomodulating and antineoplastic activities. BMS-986205 specifically targets and binds to IDO1, a cytosolic enzyme responsible for the oxidation of the amino acid tryptophan into the immunosuppressive metabolite kynurenine. By inhibiting IDO1 and decreasing kynurenine in tumor cells, BMS-986205 restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs). | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | IDO | ||
Structure
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