TG 100801 Hydrochloride
| CAS No. | 1018069-81-2 | Cat. No. | BCP25254 |
| Name | TG 100801 Hydrochloride | ||
| Synonyms | TG-100801 Hydrochloride;TG100801 Hydrochloride; | ||
| Formula | C33H31Cl2N5O3 | M. Wt | 616.54 |
| Description | TG 100801 Hydrochloride is a prodrug that generates TG 100572 by de-esterification in development to treat age-related macular degeneration. TG 100572 is a multi-targeted kinase inhibitor which inhibits receptor tyrosine kinases and Src kinases; has IC50s of 2, 7, 2, 16, 13, 5, 0.5, 6, 0.1, 0.4, 1, 0.2 for VEGFR1, VEGFR2, FGFR1, FGFR2, PDGFRβ, Fgr, Fyn, Hck, Lck, Lyn, Src, Yes, respectively. | ||
| Pathways | Angiogenesis/Protein Tyrosine Kinase | ||
| Targets | Src/Bcr Abl PDGFR VEGFR FGFR | ||
Structure
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