EG00229 Trifluoroacetate

CAS No.	1210945-69-9	Cat. No.	BCP20418
Name	EG00229 Trifluoroacetate
Synonyms	EG00229 Trifluoroacetate salt;EG-00229;EG00229;EG 00229;
Formula	C19H20F3N7O7S3	M. Wt	611.59

Description	EG00229 is the first small molecule inhibitor of the neuropilin-1 and VEGF-A interaction with an IC50 of inhibition of 8 uM(125I-VEGF binding to PAE/NRP1 cells).IC50 value: 8 uM [1] Target: NRP1/VEGF-A inhibitor EG00229 reduced VEGF-A-induced VEGFR2 tyrosine phosphorylation in HUVECs in a dose-dependent fashion, with a maximum inhibition of 34% at 100 μM. EG00229 also significantly reduced VEGF-A induced migration of HUVECs. caused a partial inhibition of VEGF receptor activity and biological function, consistent with the current model for the role of NRP1 in VEGF function, in which NRP1 is required for optimal signaling and certain biological functions downstream of VEGFR2, particularly migration.
Pathways	Angiogenesis/Protein Tyrosine Kinase
Targets	VEGFR

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