Voruciclib

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP18126CAS No. ：1000023-04-0Purity：98%

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CAS No.	1000023-04-0	Cat. No.	BCP18126
Name	Voruciclib
Synonyms	P1446A05； P1446A-05； P1446A 05；UNII-W66XP666AM;
SMILES	O=C1C=C(C2=CC=C(C(F)(F)F)C=C2Cl)OC3=C([C@]4[C@](CO)N(C)CC4)C(O)=CC(O)=C13
Chemical Name
Formula	C22H19ClF3NO5	M. Wt	469.84
Purity	98%	Storage	Store at 4-8°C
Description	Voruciclib, also known as P1446A-05, is a protein kinase inhibitor specific for the cyclin-dependent kinase 4 (CDK4) with potential antineoplastic activity. CDK4 inhibitor P1446A-05 specifically inhibits CDK4-mediated G1-S phase transition, arresting cell cycling and inhibiting cancer cell growth. The serine/threonine kinase CDK4 is found in a complex with D-type G1 cyclins and is the first kinase to become activated upon mitogenic stimulation, releasing cells from a quiescent stage into the G1/S growth cycling stage; CDK-cyclin complexes have been shown to phosphorylate the retinoblastoma (Rb) transcription factor in early G1, displacing histone deacetylase (HDAC) and blocking transcriptional repression.