AMG-208
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1002304-34-8 | Cat. No. | BCP01384 |
| Name | AMG-208 | ||
| Synonyms | AMG208;AMG 208; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C22H17N5O2 | M. Wt | 383.41 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | AMG-208 shows the potent inhibition of kinase c-Met activity with IC50 of 9 nM in a cell-free assay. Besides, AMG-208 treatment also leads to the inhibition of HGF-mediated c-Met phosphorylation in PC3 cells with IC50 of 46 nM. [1] Incubation of AMG-208 with rat and human liver microsomes in the presence of NADPH qualitatively yields C6-phenylarene oxidation products as the major metabolites. [1] Pre-incubation of AMG-208 with human liver microsomes for 30 minutes shows a potent time-dependent in | ||
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