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Cobicistat Chemical Structure

Cobicistat

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP06630CAS No. ：1004316-88-4Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1004316-88-4 Cat. No. BCP06630
Name Cobicistat
Synonyms GS 9350;GS9350; GS-9350;
SMILES
Chemical Name
Formula C40H53N7O5S2 M. Wt 776.03
Purity 98% Storage Store at 4-8°C
Description Cobicistat (GS-9350) is a potent, and selective inhibitor of human cytochrome P450 3A (CYP3A) enzymes as a pharmacoenhancer. GS-9350 inhibits CYP3A with IC50 spectrum from 30 nM to 285 nM. In contrast to ritonavir, GS-9350 is devoid of anti-HIV activity, with IC50 of > 30μM against HIV-1 protease and EC50 of > 30μM in MT-2 HIV infection assay, and is thus more suitable for use in boosting anti-HIV drugs without risking selection of potential drug-resistant HIV variants. GS-9350 shows reduced liability for drug interactions and may have potential improvements in tolerability over ritonavir.
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H-NMR
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