Ebrotidine

Data Sheet For research use only. Not for human use.

Cat. No. ：BCP13341CAS No. ：100981-43-9Purity：98%

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CAS No.	100981-43-9	Cat. No.	BCP13341
Name	Ebrotidine
Synonyms	FI 3542;FI-3542;FI3542;
SMILES
Chemical Name
Formula	C14H17BrN6O2S3	M. Wt	477.43
Purity	98%	Storage	Store at 4-8°C
Description	in vitro: Ebrotidine displaced 3H-thiotidine specific binding to histamine H2-receptors (Ki: 127.5 nmol/l), showing a higher affinity (p < 0.05) than ranitidine (Ki: 190.0 nmol/l) and cimetidine (Ki: 246.1 nmol/l) [1]. in vivo: Following intravenous administration to rats, ebrotidine inhibited histamine- and pentagastrin-stimulated acid secretion in a dose-dependent manner, ED50 being 0.21 and 0.44 mg/kg, respectively . The mean number of gastric erosions seen at endoscopy after treatment with ebrotidine plus ASA (2.0 +/- 0.3) was significantly lower than that after placebo plus ASA (3.7 +/- 0.2). This reduction in lesion core by ebrotidine was accompanied by a significant increase in gastric blood flow (by 15% in corpus and 26% in antrum), by a rise in transmucosal potential difference (by 12%), and by a decrease of mucosal microbleeding [3]. Results of macroscopic assessment revealed that ebrotidine at doses of 50mg and higher/kg body weight effectively prevented mucosal injury, and