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b-AP15 Chemical Structure

b-AP15

Data Sheet For research use only. Not for human use.
Cat. No. ：BCP08149CAS No. ：1009817-63-3Purity：98%
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  • Chemical Properties&Biological Activity
CAS No. 1009817-63-3 Cat. No. BCP08149
Name b-AP15
Synonyms LM 3077;LM3077;b-AP-15;NSC 687852;NSC-687852;NSC687852;
SMILES C=CC(=O)N1CC(=CC2=CC=C(C=C2)[N+](=O)[O-])C(=O)C(=CC3=CC=C(C=C3)[N+](=O)[O-])C1
Chemical Name
Formula C22H17N3O6 M. Wt 419.39
Purity 98% Storage Store at 4-8°C
Description b-AP15 is a novel inhibitor of proteasome deubiquitination. b-AP15 displays antitumor activity in several preclinical, solid tumor models. b-AP15 triggers time- and dose-dependent apoptosis of the human multiple myeloma (MM) cell lines RPMI8226 and U266, as determined by phosphatidylserine exposure. Furthermore, b-AP15 triggered processing of pro-caspase-3 and cleavage of poly (ADP-ribose) polymerase in MM cells. b-AP15 also induced caspase-independent apoptosis in primary human natural killer cells. b-AP15 may have potential for treatment of multiple myeloma patients.
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