Tenovin6 Hydrochloride
Data Sheet
For research use only. Not for human use.
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| CAS No. | 1011301-29-3 | Cat. No. | BCP18122 |
| Name | Tenovin6 Hydrochloride | ||
| Synonyms | Tenovin-6 Hydrochloride;Tenovin 6 Hydrochloride; | ||
| SMILES | |||
| Chemical Name | |||
| Formula | C25H34N4O2S.HCl | M. Wt | 491.09 |
| Purity | 98% | Storage | Store at 4-8°C |
| Description | Inhibition of the Sirtuin class of protein deacetylases with activation of p53 function is associated with the pro-apoptotic effects of Tnv-6 in many tumors. Tnv-6 causes non-genotoxic cytotoxicity, without adversely affecting human clonogenic hematopoietic progenitors in vitro, or murine hematopoiesis. Mechanistically, exposure of CLL cells to Tnv-6 did not induce cellular apoptosis or p53-pathway activity. Transcriptomic profiling identified a gene program influenced by Tnv-6 that included autophagy-lysosomal pathway genes. | ||
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